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Schramm (Woodward and Schramm, 1947)] and noted that they showed a noteworthy similarity to a film of denatured keratin (Darmon and Sutherland, 1947)

Theres no strong human evidence to support spot-reduction claims

Stability over time also affects effective concentration

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While additional studies are needed to determine whether elevated vitamin B 12 status may be related to cancer development, including evaluating whether it might be a potential marker of cancer, it is important for observational studies to adequately control for potential confounders, such as age, menopausal status, alcohol use, and intake of the B-vitamin folate

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