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One concern was potential adenoma growth caused by the increased levels of circulating GH

The molecule is structurally modified with an N-terminal trans-3-hexenoyl group, which dramatically reduces its susceptibility to dipeptidyl peptidase IV (DPP-IV) degradation, the enzyme that breaks down natural GHRH

Concurrently, it enhances antioxidant defenses through SOD2 and nuclear factor erythroid 2-related factor 2 (Nrf2) upregulation (43), ameliorating hepatic inflammation in NAFLD models

Navrot et al

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