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Modelling amyotrophic lateral sclerosis in rodents

Gln depletion therapy can inhibit Gln metabolism in tumor cells, but in colon cancer, it has been observed that Gln depletion promotes the expression of the aspartate/glutamate transporter SLC1A3 in tumor cells, increasing the intracellular glutamate concentration and promotes Gln synthesis

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A: After exposure to UV radiation (UVB, 5 mJ/cm2 for 1 min), control and HPV-16 E7-expressing HaCaT cells showed a significant correlation between HPV-16 E7 expression and cell survival (p = 0.000003, ***)

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