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10.1021/bi00397a039 448 OkunukiK.HagiharaB.MatsubaraH.NakayamaT

Until recently, those medications meant having to give yourself an injection

Some approved drugs are themselves peptides, such as: Insulin GLP-1 receptor agonists Calcitonin Oxytocin Such success has spurred scientists to look into even more potential therapeutic peptides

Acknowledgements This work was supported by grants from National Institute of Diabetes and Digestive and Kidney Diseases (R01DK121804) and National Institute of Food and Agriculture (67017-29252) Ethics declarations Competing interests The authors declare no competing interests

The DIY option uses separate vials of each peptide

Because orforglipron is a small molecule, it doesnt require the complex biological manufacturing or cold-chain logistics that peptide drugs like semaglutide demand