found that FITC-insulin retained in the epidermis after electroporation was primarily transported through lipid multilayers around the corneocytes [197]
In addition, many diseases are considered undruggable using standard biomacromolecules
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Critical Reviews on Toxicology 23(1):2148 Kielstein J, Bode-Boger S, Klein G, Graf S, Haller H, Fliser D (2003) Endogenous nitric oxide synthase inhibitors and renal perfusion in patients with heart failure
Results: Medium and high doses of ATT-I significantly alleviated DSS-induced colitis symptoms by reducing histological damage, preventing colon shortening, decreasing spleen index and cytokine levels, and improving epithelial integrity