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Moreover, a significant fraction of subjects, commonly referred to as treatment-resistant, do not respond to these antidepressants despite the use of various therapeutic strategies (173)

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recently reported that the glucoregulatory improvements of DPP-IV inhibitors are dependent on pancreatic proglucagon-derived factors in vivo (15), suggesting that these pancreatic peptides are critical substrates for the inhibitory effects of DPP-IV

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[16] [19] Some research suggests these anti-inflammatory effects may occur alongside weight loss, though the relative contributions of direct immunomodulation versus metabolic improvement remain unclear