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Read our explainer to fully understand just what is an IRA CD
The meta-analysis included 16 studies including patients with asymptomatic hyperuricemia and/or gout treated with febuxostat and were compared with placebo/allopurinol, demonstrating a significant reduction in renal events (doubling of serum creatinine concentration and/or entry into renal replacement therapy): HR 0.56, 95% CI 0.370.84, p = 0.006 and a slight decrease in the fall of glomerular filtration rate (0.90 ml/min/1.73 m2) and in albuminuria.49 Like the observed with allopurinol, there is currently insufficient evidence to suggest treatment with febuxostat for renal or cardiovascular protection in patients with asymptomatic hyperuricemia
Antioxidants 10(6):967 Wells G, Shea B, OConnell D, Peterson J, Welch V, Losos M, Tugwell P (2021) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses
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This can be quite expensive, especially with the additional maintenance sessions
