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Some data suggests that the area accessible to G-proteins on the receptor is insufficient for transduction of the receptor signal to the relatively large trimeric G-protein complex (Park et al., 2004)

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Healthy aging is defined as the accumulation of time dependent cellular damage which factors include oxidative stress, epigenetic changes, genomic instability, telomere attrition, and dysregulation of cell signaling and inflammatory responses, upon further hit, this natural disruption may become detrimental [53]

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In animal studies, offspring with prenatal exposure to valproate had malformations similar to those seen in humans and demonstrated neurobehavioral deficits [seeUse in Specific Populations (8.1)]

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