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As peptide bonds break down, byproducts can form that trigger immune responses or localized injection-site reactions

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Supplementary Materials The following supporting information can be downloaded at: Table S1: Antioxidant activity of amino acids using ABTS radical scavenging assay

PT-141 was derived from Melanotan II by removing the cyclic lactam bridge to produce a linear metabolite with reduced MC1R affinity while retaining MC3R and MC4R agonism, effectively separating melanogenic activity from central nervous system-mediated behavioral effects

The signal is there, but its too weak to make a difference