A detailed family history should include the specific type of thyroid cancer, age at diagnosis, and whether multiple family members have been affected, as these factors help determine hereditary risk and appropriate screening strategies
doi:10.1080/17474086.2020.1831383 119
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Thus, combining chemical structure modifications of nucleic acids with advanced drug delivery systems could achieve enhanced therapeutic effects
Moreover, WES allows for the integration of pharmacogenomic information, particularly exonic variants in genes related to the Absorption, Distribution, Metabolism, and Excretion (ADME) of drugs, which may complement targeted assays traditionally used to calculate pharmacogenetic profiles, with the possibility of expanding the understanding of gene-drug interactions, and indirectly inform potential drugdrug and drug-nutrient interactionswhich will necessarily have to be calculated through other platforms (Whirl-Carrillo et al., 2012)