10.1038/s41598-024-52143-y 158
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Furthermore, a meta-analysis of data from large cardiovascular outcome trials (CVOT) demonstrates that GLP-1RA therapy does not seem to elevate the risk of pancreatic cancer in patients with T2DM [7]
Several recent studies have pointed out that alterations of the gut microbial tryptophan metabolism influence peripheral Trp availability, affecting central tryptophan levels and, thereby, leading to changes in the central serotonin metabolism (171, 172)