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J Exp Ther Oncol, 2012

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11 The management of CVD and renal co-morbidities is essential in patients with gout

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Free radicals play critical role in generating oxidative stress, which oxidizes dopamine to dopamine quinone and superoxide anion and decreases the NADPH and dopamine metabolized by MOA that produces the 3,4-dihydroxyphenylacetaldehyde, ammonia, and H 2 O 2 , which in turn interacts with Fe ++ to generates the OH free radicals that kill neurons in PD [61, 62]

Further RCTs of high quality are still needed to clarify this issue