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Longitudinal studies are needed to further investigate the cause-effect relationship between VitB12 and insomnia and establish a safe and adequate VitB12 supplementation level in patients with T2DM

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Biochem Biophys Res Commun (2016) 470(3):53945

doi: 10.18632/oncotarget.20278

Biomarker validation requires large-scale studies in diverse populations that are expensive and time-consuming to conduct

Although one thought may be through the upregulation of neurotransmitters in which are directly correlated with Testosterone, specifically dopamine