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Therefore, we refolded open-HLA-C*04:01 with the HLA-C*05:01 binding peptide P2-EE (IIDKSGEEV) that lacks the aromatic p2 anchor commonly seen in HLA-C*04:01 binding peptides

The authors proposed that MOTS-c levels could serve as a predictive indicator for aerobic capacity, body-fat status, and endurance training load.14 This raises an intriguing possibility for endurance practitioners: MOTS-c as a blood-based biomarker for mitochondrial fitness, complementing VOmax and lactate threshold in a multi-modal assessment framework

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