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Ghasemi A, Norouzirad R

Conclusions Botox for the treatment and prevention of chronic migraine has been a game changer for many patients

Most studies have been conducted on rodents and focus on short-term healing outcomes

The BBB, composed of tightly joined endothelial cells, astrocytic end-feet, and pericytes, serves as a selective barrier that regulates the passage of substances from the bloodstream into the brain parenchyma (Oldendorf, 1971), while macromolecules such as transferrin and insulin use endothelial receptor-mediated transport (Nance et al., 2022)

2a), and time of the reaction from 1 to 30 min (Fig

May improve mood, reduce inflammation, and prevent chronic diseases