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In rat wound healing studies, collagen synthesis increased 9-fold with peptide-incorporated collagen dressings

Precautions include avoiding use in those with cobalt allergy

Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the upregulation of epidermal growth factor expression on VEGFR1+ CXCR4+ cells recruited from bone marrow

LIMITATIONS OF THIS SNAPSHOT Do not rely on Snapshots to make decisions regarding medical care

Vairetti M, Di Pasqua LG, Cagna M, Richelmi P, Ferrigno A, Berardo C

Upon tissue injury, it is released from collagen and other matrix proteins, where it arises as a fragment of the alpha-2 chain of type I collagen (Pickart et al., 2018)