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6.3 Vitamin B12 Deficiency Vitamin B12 deficiency represents a critical confounding factor in the diagnosis of DPN, as neuropathy itself is fundamentally a diagnosis of exclusion requiring the elimination of other potential etiologies [157]

The accumulation of lipid peroxides in cell membranes alters membrane permeability and stability, leading to membrane rupture and ultimately triggering ferroptosis (36, 37)

doi: 10.1016/j.clgc.2019.07.009 42 LiFXiangHPangZChenZDaiJChenSet al

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