One example is indole-3-propionic acid (IPA), which is one of the iodole derivatives produced by the gut bacteria during tryptophan catabolism
However, it was not possible to obtain the initial results again, and this compound was also excluded from clinical trials ( in vitro , so its activity may be due to other mechanisms of action (Maples et al., 2001)
A randomized, double-blind, positive-controlled, prospective, dose-response clinical study to evaluate the efficacy and tolerability of an aqueous extract of Terminalia bellerica in lowering uric acid and creatinine levels in chronic kidney disease subjects with hyperuricemia
No.: JK/21-22/COS-8/334
J Biol Chem 282:56415652 Satue M, Obis J, Rodrigo MJ, Otin S, Fuertes MI, Vilades E, Gracia H, Ara JR, Alarcia R, Polo V, Larrosa JM, Pablo LE, Garcia-Martin E (2016) Optical Coherence Tomography as a Biomarker for Diagnosis, Progression, and Prognosis of Neurodegenerative Diseases
D.IvashkivL
