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Overall evidence, however, does not support this causality

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Al Shweiki MR, et al

Their mechanism in this context involves the downregulation of pro-inflammatory cytokines including interleukin-1 alpha and tumor necrosis factor that directly damage follicular epithelium and disrupt the dermal papilla's signaling function

165,206 Few studies have examined the role of vitamin B 6 on homocysteine-related disorders independently of folate and B 12 , but a meta-analysis with a total of 369,746 participants determined higher intake of B 6 was correlated with lower risk of coronary heart disease