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[DOI] [PubMed] [Google Scholar] 76.Lucena MI, Andrade RJ, Kaplowitz N, Garca-Cortes M, Fernndez MC, Romero-Gomez M, et al

The rationale is straightforward: these peptides work through complementary mechanisms, and together they may address more aspects of disc healing than either can alone

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NNMT is an enzyme that methylates nicotinamide (a form of vitamin B3), converting it to N1-methylnicotinamide and effectively removing it from the NAD+ salvage pathway

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Safety, particularly regarding immunogenicity, constitutes another critical challenge