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Many patients and doctors consider it a starting point when newer agents are unavailable or too expensive

Notably, more than 30% of patients dropped out of treatment after the first month

2017;40(Suppl

2004 Jun;1019:502-5

Metformin boosts growth differentiation factor 15 (GDF15) expression , a peptide hormone that helps reduce appetite

Examining whether photoprotection in EPP biology reflects melanin-dependent light attenuation, melanin-independent DNA repair enhancement, anti-inflammatory signalling, or combinations of these mechanisms