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1 Introduction 1.1 Atherosclerosis and coronary artery disease Coronary artery disease (CAD) is a cardiovascular condition occuring due to atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive ( Inflammation plays a key role in the formation of atherosclerotic plaquesthe primary pathological mechanism underlying CAD ( (IFN- ) and tumour necrosis factor (TNF)- , produced by immune cells, endothelial cells, platelets and fibroblasts are associated with atherosclerosis onset and progression

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Over time with rapid weight loss: facial volume loss (Ozempic face) or loose skin can appear, especially in people with a lower starting BMI

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Hip circumference drops 3 to 6 inches

No dose adjustments are recommended for patients with renal impairment