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The doses approved by regulatory bodies have been determined through rigorous phase III clinical trials involving thousands of participants, with careful assessment of both efficacy and safety profiles

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After a minimum of 4 weeks, the dose increases to 5 mg

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doi:10.1161/CIRCULATIONAHA.116.021887 60

The cycle half-life of GLP-1 (7-36)NH 2 is 23 min, and the truncated metabolites are usually considered inactive