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Fibroblast-like synoviocytes (FLSs) contribute to pannus formation and matrix degradation through MMP-1 and MMP-3, with expression levels 5 - 10 times higher in RA synovium (Figure 1) (14)
10.1016/j.ydbio.2021.03.013 41 DogruM.KojimaT.SimsekC.TsubotaK
The result is a synergistic pulse that is significantly larger than either peptide alone, while still being a physiological pulse rather than a pharmacological spike
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An anaphylactic reaction usually requires administration of epinephrine
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