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FIGURE 1 In terms of dosage, there is little difference between the physiological and pharmacological effects of melatonin, physiological dose provides plasma melatonin levels of the same order of magnitude as a nocturnal peak (less or around 100 pg/ml or 400 pM)

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[15] [14] While mild gastrointestinal symptoms are common and often transient with GLP-1 therapy, certain warning signs warrant prompt medical evaluation