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conducted a meta-analysis of data from 11 randomized controlled trials and found that corticosteroids can reduce the risk of death within 28 days of treatment (Louvet et al., 2018)

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A pragmatic way forward is to (i) use Bayesian inference to express uncertainty in clinically interpretable probabilities, and (ii) use data-driven phenotyping (including ML-enabled clustering where appropriate) to describe heterogeneity in treatment response

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