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The only difference is in their half-lives (how long they stay active in your body)

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Specifically, the inhibition of Nrf2 ubiquitination increases nuclear Nrf2 retention and ARE-Nrf2 binding affinity (Rizvi et al., 2015a)

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0.33g of the crude Boc-His (Trt) -Aib-OSu and 1g of the compound 2 obtained in example 1 were dissolved in 20mL of N, N-dimethylformamide, and 2mL of N, N-diisopropylethylamine was added and reacted at room temperature for 8 hours to obtain the compound 4 having a purity of 76.57%, and a specific liquid phase diagram is shown in FIG