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Additionally, when the genes involved in taurine transport are knocked out in mice, it leads to cardiomyopathy.[ref] Heart failure: In the 1980s, clinical trials using supplemental taurine showed benefits for heart failure patients

Clinical Endocrinology , 81(2), 312-319

a Indicates any peripheral arterial disease, claudication, critical limb ischemia, endovascular therapy, peripheral bypass, or nontraumatic amputation

These results were more difficult to explain as the mouse plasma half-life of 11 is prolonged (31 min) and the potency (13%) is comparable to 14 (6%), 22 (19%) and 23 (7%)

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Research indicates that skin lightening products can achieve moderate results for skin lightening and health improvement but they do not produce significant whitening effects