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Similar concept to peptides (delivering growth signals) but different mechanism (autologous growth factors from patient's blood)

The near-balanced peptide was shown to be ~2-fold less potent at GLP-1R and ~10 fold less potent at GCGR than native ligands in cAMP synthesis (75)

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The liver fat reduction is already substantial at this dose level, with 79% of MASLD trial participants achieving normal liver fat at 8mg

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Cells were washed three times in 500 l PBS, lysed with 0.2% Triton X-100 at 37 C for 10 min and plated on LB agar