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MOTS-c handles cellular energy regulation, metabolic flexibility, and mitochondrial signaling

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D.HarrisonS.et al

For people with type 2 diabetes who are switching from an SGLT2 inhibitor to tirzepatide, the UTI benefit can be particularly noticeable

Furthermore, adaptive mutations in NS3 and NS5B map to surface residues distant from the enzyme active sites, suggesting that these changes are likely to affect interactions between NS proteins and/or cellular factors