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The same authors also showed [59, 70] that the action of both CAT and GPx was insufficient to explain the erythrocyte oxidative catabolism, and proposed [70] a model including Prx2 that, in accordance with their experimental data, could better explain the erythrocyte antioxidant defense system
The liver is primarily responsible for hepatic metabolism of acetaminophen, while the kidneys handle the renal clearance of ibuprofen
& Dietrich, T
Native oral GSH absorption measures 0.7 0.1% due to enzymatic degradation in the gastrointestinal tract
In conclusion, the present review summarized the role of ferroptosis in the pathology of AD and how mechanisms such as iron metabolism disorders, lipid peroxidation and GSH depletion lead to neuronal damage, as well as the role of ferroptosis inhibitors such as vitamin E, Se and Fer-1 as potential therapeutic strategies
