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5a), a pro-drug that combines sulphapyridine (an antibiotic) and 5-aminosalicylic (an anti-inflammatory agent) linked by an azo bridge, has huge therapeutic potential, but is, unfortunately, labile under physiological conditions (70% degradation by colonic bacteria via azo cleavage

Whereas ATF4 and CHOP enhance defense against redox disturbance and reactive oxygen species (ROS) (Rouschop et al