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Metabolism & Elimination PT-141 undergoes metabolism primarily through hydrolysis of peptide bonds , a typical degradation pathway for peptide therapeutics
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You might think that would at least coincide with a superior safety profile, but that same study saw a greater rate of trial discontinuation due to adverse effects in the liraglutide group than in the semaglutide group.7 It also requires daily dosing, which is less convenient than the weekly administration of semaglutide and tirzepatide
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