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Months 3-6: Long-Term Pattern What clinical data documents: The longest human dataset is the long-term observational study of 115 EPP patients treated with afamelanotide implants over a period of up to 8 years, which reported sustained clinical benefit and good tolerability under routine long-term use (Biolcati et al., 2015)

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Be cautious regarding cosmetic claims without scientific evidence

Advise patients to call their prescriber if they take more than the recommended dose

At the molecular signaling level, the combination produces simultaneous activation of pathways that are normally activated in sequence during natural wound healing