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Since rapamycin treatment inhibits the alteration of PIP 3 and PTEN levels under insulin-resistant conditions, it is believed that the mTORC1 is involved in negatively regulating the IRS-1/PI3K/AKT signaling cascade downstream of the insulin receptor

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doi: 10.1046/j.1523-1755.2003.00189.x 87 Riquier-BrisonADLeongPKPihakaski-MaunsbachKMcDonoughAA