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Additionally, UA promotes skeletal muscle angiogenesis through modulation of the silent information regulator 1 and peroxisome proliferator-activated receptor-gamma coactivator-1-alpha signaling pathways, resulting in increased capillary density and improved muscular endurance (8)

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Peer review Peer review information Nature Medicine thanks Philip Cowen, Boris Heifets, Taeho Greg Rhee and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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