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Indeed, both in rodents and humans, GLP-1 infusion increased fractional sodium excretion [20], which has been linked to the finding that sodium is more rapidly excreted following an oral versus equivalent IV sodium load in a number of experimental studies in healthy individuals, independent of factors such as atrial natriuretic peptide (ANP) and aldosterone [22]

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The most significant benefits, though, were psychological

GLP-1R activation increases the recruitment of the fission protein Drp1 to mitochondria and enhances mitophagy, thereby removing damaged organelles and protecting tissues from oxidative stress (Torres et al., 2016)

Your provider sets your starting dose and a titration schedule, then adjusts it over time based on how you respond