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Safety Considerations and Future Outlook As with all pharmacotherapy for obesity and T2D, establishing cardiovascular safety and demonstrating improvements in meaningful clinical outcomes will be essential, particularly as cardiovascular outcome trials have not yet been completed with multi-agonists (although data are expected soon for tirzepatide: SURPASS-CVOT [T2D] in 2025

The pharmaceutical industry continues investing heavily into next-generation obesity therapies capable of improving efficacy and patient experience

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doi: 10.1177/019262338901700205 14 ElashoffMMatveyenkoAVGierBElashoffRButlerPC

Gradual Dose Adjustments Starting slowly and following your providers titration plan is one of the most effective ways to prevent side effects