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Ferro, P., Krotov, G., Zvereva, I., Rodchenkov, G

El GLP-1R se encuentra en mltiples tejidos perifricos como pncreas, intestino, rin, tejido mamario, pulmn, corazn y cerebro 19,20 , mediando la activacin de la protena cinasa A (PKA) o del factor intercambiador de nucletidos de guanina regulador por AMPc (EPAC) (Figura 2) 21

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While the preclinical safety profile appears favorable (few adverse effects reported in animal studies), this does not guarantee the same in humans, especially with prolonged use

doi: 10.1016/j.placenta.2005.10.002

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