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Journal of Neuroscience 26, 1051410523CrossRefGoogle ScholarPubMed 78Yoh, K., Itoh, K., Enomoto, A

In summary, QUEs dual, dose-dependent naturecharacterized by protective effects at low doses and toxic effects at high doseshighlights its double-edged sword status

Decrease dose consideration: Persistent side effects including headaches, fatigue, or injection site reactions, excessive response (extremely rapid weight loss suggesting dose may be higher than needed), cost concerns when lower doses might achieve similar results

These goals matter

One of methylations most important functions is regulating gene expression

The side-effect risk is just as high (or greater if uncontrolled)