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Abbreviations ADA: Anti-drug antibody ANDA: Abbreviated new drug application APC: Antigen presenting cell API: Active pharmaceutical ingredient GDUFA: Generic drug user fee amendments HLA: Human leukocyte antigen LC-MS: Liquid chromatography-mass spectrometry MAPPs: MHC-II-associated peptide proteomics MHC: Major histocompatibility complex MMF: Model master file PBMC: Peripheral blood mononuclear cell RLD: Reference listed drug SPPS: Solid phase peptide synthesis TCR: T cell receptor References U.S

doi:10.1146/annurev.physiol.64.081501.131029

doi:10.1093/toxres/tfab009 45

GLP-1s are most effective when combined with healthy eating and regular exercise

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