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Key Takeaways Side effects are predictable, dose-dependent, and time-limited for most patients Nausea typically peaks within 48 weeks and improves with body adaptation Each dose escalation produces a temporary, milder return of symptoms Weeks 26 are when most patients quit this is the wrong time to stop Protein, hydration, and resistance training prevent the most common long-term issues (muscle loss, fatigue, constipation) Serious side effects are uncommon but recognisable knowing the warning signs matters If symptoms are unmanageable, ask your prescriber to delay (not skip) a dose escalation References Hawkins-Jarrett ZC, PharmD

Nonetheless, published data suggest outcomes are still poor: FormBlends observed that only 32% of initial Wegovy PAs went through (68% denied) at Express Scripts in 202425 data ( [3] )

This is crucial for long-term weight maintenance

The prevalence of HSV and VZV infections is notably higher among diabetic patients compared to the general population, which may be attributed to the immunocompromised state associated with DM [14, 15]

Build from clinical data, not assumptions