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Cardiovascular Safety The SELECT trial evaluating cardiovascular outcomes in patients with obesity and established cardiovascular disease demonstrated that serious adverse events were actually lower with semaglutide versus placebo (33.4% vs 36.4%), primarily driven by fewer cardiac disorders (11.5% vs 13.5%)

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These trends suggest that GLP-1s are reshaping treatment patterns most significantly in markets where few alternatives exist and where their effectiveness is increasingly valued

Night sweats, medically termed nocturnal hyperhidrosis, can result from numerous medical conditions and should be evaluated comprehensively

Injectable semaglutide formulations (Ozempic, Wegovy) do not have these timing restrictions