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Multiple studies have indicated that the overexpression of GLS observed in many cancers may not only decrease glutamine levels but also elevate intratumoral glutamate levels [173, 174]

It means protocols become unreliable, results are inconsistent and dose-response cannot be properly evaluated

Two independent studies have demonstrated that the deletion of Tnfr1 lowered liver regeneration after APAP overdose in mice.36, 37 However, overall recovery was not altered in one of these studies 37 and Tnfr1 KO mice were found to be more susceptible to initial APAP toxicity in the other study

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Therefore, this review aims to analyze and summarize the detoxification mechanisms of selenium yeast to mycotoxins and heavy metal poisoning, and will help to inform future studies investigating the effects of selenium yeast