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The TriNetX platform has been used in retrospective cohort studies [25,26,27,28,29,30,31,32,33,34,35,36,37,38] including evaluating risk and health outcomes of patients with substance use disorders including CUD [25, 32, 35] and the associations of GLP-1RAs with cancer [37] and semaglutide with suicidal ideations [38]

There is a growing market for unlicensed, compounded, or counterfeit peptides sold online, and the MHRA has issued warnings about the serious risks associated with purchasing injectable medicines from unregulated sources including contamination, incorrect or unknown dosing, and harmful impurities

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Back then, the underground market operated much less openly