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Signs you should slow down the titration Extend your stay at the current dose by 2-4 additional weeks if you experience any of the following at the end of a standard 4-week period: Nausea persisting beyond the first 7 days after the last dose increase Vomiting more than twice per week Diarrhea lasting more than 10 days at the current dose Significant fatigue or weakness that does not improve with adequate nutrition and rest Weight loss exceeding 1.5% per week (too-rapid loss increases gallstone risk and muscle loss) Slowing the titration is not failure

N Engl J Med 377(7):644657

If a pen or vial accidentally freezeseven if it thaws afterwardit must be discarded

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Individuals will be able to fill their pre-approved prescriptions at local retail pharmacies and directly through Novo Nordisk or Ely Lillys direct to consumer mail order pharmacies.