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The early phase begins within minutes of eating, when nutrients in the upper gastrointestinal tract trigger neural and hormonal signals that stimulate L-cells even before food reaches the distal intestine

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New England Journal of Medicine , 384 (11), 989-1002

Small-molecule albumin ligand modification to enhance the anti-diabetic ability of GLP-1 derivatives

Diabetologia 65 , 12511261 (2022)

The evidence supports supervised medical weight management producing better outcomes than independent attempts