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6 Treatment can then be stepped up as required, depending on the severity of symptoms (Table 1)

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*Correspondence: Chen Chen, [email protected] Guo, [email protected] These authors have contributed equally to this work This article was submitted to Molecular Signalling and Pathways, a section of the journal Frontiers in Molecular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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