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Clinical Implications and Remaining Gaps Modeling studies suggest that the cumulative impact of combination therapy may be substantial, with meaningful gains in cardiovascular and kidney event-free survival when implemented early in high-risk populations [38]

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Similarly, in primary cardiac fibroblasts, GLP-1R agonism inhibited TGF- signalling activity and expression of ECM proteins, including COL1A1 and COL3A1 [25]

In the United States, list prices for GLP-1 drugs have historically ranged between $1,000 and $1,300 per month