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The high plasma urea values around calving result from the intense catabolism of amino acids destined for cortisol-induced gluconeogenesis ( Hammon et al., 2005 )

Standard titration is the FDA-approved process of starting at a low dose (typically 2.5 mg) and increasing every four weeks until a maintenance dose is reached to achieve the significant weight loss seen in clinical trials

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For instance, NLY01, a long-acting PEGylated GLP-1RA with an extended half-life [41], effectively mitigates retinal ganglion cell (RGC) apoptosis induced by elevated intraocular pressure, a process mediated by a well-defined inflammatory cascade [44]

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